Correlation of dopamine transporter imaging with parkinsonian motor handicap: How close is it?
Identifieur interne : 001795 ( Main/Exploration ); précédent : 001794; suivant : 001796Correlation of dopamine transporter imaging with parkinsonian motor handicap: How close is it?
Auteurs : Walter Pirker [Autriche]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-10.
English descriptors
- KwdEn :
Abstract
During the past decade, dopamine transporter (DAT) imaging with single photon emission computerized tomography (SPECT) or positron emission tomography (PET) has evolved as an objective in vivo marker of nigrostriatal neuron loss in Parkinson's disease (PD). We investigate the relationship between striatal DAT binding, measured with [123I]β‐CIT SPECT, and parkinsonian motor handicap in a sample of 59 PD patients with minimal to severe disability, and review published cross‐sectional studies on the correlation between DAT imaging and motor symptoms in PD. Earlier studies as well as the present results show a good correlation between overall striatal DAT binding and global measures of disease severity such as the Hoehn and Yahr scale, the total score on the Unified Parkinson's Disease Rating Scale (UPDRS), and UPDRS activities of daily living, with a progressive decline of DAT binding with increasing disability. A number of studies found a significant inverse correlation of striatal DAT binding with UPDRS motor score. Bradykinesia, posture, gait, and other midline symptoms, such as speech and facial expression, compared with rigidity, seem to be more closely related to striatal DAT binding. By contrast, neither the severity of parkinsonian rest nor of action tremor is related to the degree of dopaminergic denervation as measured by DAT imaging. Motor symptoms in the clinically less affected body side show a closer correlation with striatal DAT binding than do symptoms occurring in the dominantly affected body side. The correlation of putamen and caudate DAT binding with parkinsonian motor handicap seems to be similar. Although there have been limited comparative studies applying [18F]fluorodopa PET and DAT imaging in the same group of PD patients, available data suggest that putamen [18F]fluorodopa uptake, when compared with striatal DAT binding, may be more closely related to parkinsonian motor handicap. © 2003 Movement Disorder Society
Url:
DOI: 10.1002/mds.10579
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Correlation of dopamine transporter imaging with parkinsonian motor handicap: How close is it?</title><author><name sortKey="Pirker, Walter" sort="Pirker, Walter" uniqKey="Pirker W" first="Walter" last="Pirker">Walter Pirker</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:EE5E852D2FAD10ECDAA841B72FF380AB478A3006</idno><date when="2003" year="2003">2003</date><idno type="doi">10.1002/mds.10579</idno><idno type="url">https://api.istex.fr/document/EE5E852D2FAD10ECDAA841B72FF380AB478A3006/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000909</idno><idno type="wicri:Area/Main/Curation">000792</idno><idno type="wicri:Area/Main/Exploration">001795</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Correlation of dopamine transporter imaging with parkinsonian motor handicap: How close is it?</title><author><name sortKey="Pirker, Walter" sort="Pirker, Walter" uniqKey="Pirker W" first="Walter" last="Pirker">Walter Pirker</name><affiliation wicri:level="3"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2003-10">2003-10</date><biblScope unit="volume">18</biblScope><biblScope unit="issue">S7</biblScope><biblScope unit="supplement">7</biblScope><biblScope unit="page" from="S43">S43</biblScope><biblScope unit="page" to="S51">S51</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">EE5E852D2FAD10ECDAA841B72FF380AB478A3006</idno><idno type="DOI">10.1002/mds.10579</idno><idno type="ArticleID">MDS10579</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>PET</term><term>Parkinson's disease</term><term>SPECT</term><term>UPDRS</term><term>dopamine transporter</term><term>motor handicap</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">During the past decade, dopamine transporter (DAT) imaging with single photon emission computerized tomography (SPECT) or positron emission tomography (PET) has evolved as an objective in vivo marker of nigrostriatal neuron loss in Parkinson's disease (PD). We investigate the relationship between striatal DAT binding, measured with [123I]β‐CIT SPECT, and parkinsonian motor handicap in a sample of 59 PD patients with minimal to severe disability, and review published cross‐sectional studies on the correlation between DAT imaging and motor symptoms in PD. Earlier studies as well as the present results show a good correlation between overall striatal DAT binding and global measures of disease severity such as the Hoehn and Yahr scale, the total score on the Unified Parkinson's Disease Rating Scale (UPDRS), and UPDRS activities of daily living, with a progressive decline of DAT binding with increasing disability. A number of studies found a significant inverse correlation of striatal DAT binding with UPDRS motor score. Bradykinesia, posture, gait, and other midline symptoms, such as speech and facial expression, compared with rigidity, seem to be more closely related to striatal DAT binding. By contrast, neither the severity of parkinsonian rest nor of action tremor is related to the degree of dopaminergic denervation as measured by DAT imaging. Motor symptoms in the clinically less affected body side show a closer correlation with striatal DAT binding than do symptoms occurring in the dominantly affected body side. The correlation of putamen and caudate DAT binding with parkinsonian motor handicap seems to be similar. Although there have been limited comparative studies applying [18F]fluorodopa PET and DAT imaging in the same group of PD patients, available data suggest that putamen [18F]fluorodopa uptake, when compared with striatal DAT binding, may be more closely related to parkinsonian motor handicap. © 2003 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Autriche</li></country><region><li>Vienne (Autriche)</li></region><settlement><li>Vienne (Autriche)</li></settlement></list><tree><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Pirker, Walter" sort="Pirker, Walter" uniqKey="Pirker W" first="Walter" last="Pirker">Walter Pirker</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001795 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001795 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:EE5E852D2FAD10ECDAA841B72FF380AB478A3006
|texte= Correlation of dopamine transporter imaging with parkinsonian motor handicap: How close is it?
}}
| This area was generated with Dilib version V0.6.23. |  |